Technical specifications and characteristics
HORIBA OpenPlex
www.sprimaging.com
OWLS 210
www.owls-sensors.com
Biacore X100
www.biacore.com
Biacore T200
www.biacore.com
EVA2.0
www.pcbiosensors.com
Detection
technology
SPR sensor Optical Waveguide
Lightmode Spectroscopy
Surface Plasmon Resonance (SPR) sensor Photonic Crystal Surface
Waves (PC SW) sensor
Working surface Gold (Au) metal oxides with high RI (Ta2O5, TiO2 etc.)Gold (Au) Silica (SiO2)
Max adlayer
thickness
~ 100 nm ~ 1000 nm 100 nm ( ≈ penetration depth of SP wave) ~ 1000 nm
Flow rate range (not specified)0.1 to 30 000 μL/min1 to 100 μL/min 50 to 1000 μL/min
Flow cell height 70 μm 100 to 800 μm50 μm 40 μm 50 to 100 μm
Flow cell volume 11 μL 1.5 to 12 μL0.05 μL 0.06 μL 5 to 10 μL
Sample volume 50 to 2000 μL (Delivered with 200μL sample loop)20 to 500 μL5 to 90 μL 2 to 350 μL 50 to 200 μL
Number of
flow cells
3 1 2 4 1 to 12
(registration channels)
time resolution (not specified) 1 to 3 sec (not specified) (not specified) 0.1 to 10 sec
baseline noise, dne 3×10-6 RIU 3×10-6 RIU 10-7 RIU ( ≈  0.1 RU) 3×10-8 RIU ( ≈ 0.03 RU)) 5×10-8 RIU/√{Hz}
baseline noise, dma 10 pg/mm2 (optional 5 pg/mm2) 10 pg/mm2 0.2 pg/mm2 0.06 pg/mm2 0.07 (pg/mm2)/√{Hz}
baseline drift (not specified)(not specified)0.3 (pg/mm2)/min 0.3 (pg/mm2)/min 0.1 (pg/mm2)/min
Dimensions (W x D x H) 304 x 480 x 490 mm (not specified)596 x 593 x 563 mm 600 x 690 x 615 mm 215 x 443 x 135 mm
Net weight 13 kg (not specified)47 kg 60 kg 6.5 kg
price (EUR) 70 000 60 000 114 421 386 958 39 000
The exploitation of the 1D PCs as substrates supporting the long-range surface wave propagation permits researchers to:
(1) increase the sensitivity of PC SW biosensors to the level da ~ 7×10-14 m/Hz1/2 (that corresponds to mass sensitivity ma ~ 70 fg/mm2),
(2) segregate surface and volume events in biosensing (that may be an important advantage in applications where temperature and composition of the liquid under study vary over a wide range),
(3) enhance the detection of RI variation in the Abbe-like refractometer to the level ne ~ 5×10-8 RIU/Hz1/2,
(4) work with thick target ligands, such as living cells, with thickness up to 1μm
(5) obtain one-dimensional spatial selectivity that makes multichannel registration possible and increases throughput of the sensor,
(6) use the same PC chip many times, since a thick final SiO2 layer may be effectively cleaned by some active treatment (e.g., in a plasma cleaner).